Surge testing is to take place in the north London area of Barnet after cases of the South African variant of COVID-19 were detected there.
Health officials, from Thursday, will test people for the variant in specific postcode areas affected in N3 or those who shop on the local high street.
A Mobile Testing Unit will be set up in Finchley Central Station car park and teams will be going door-to-door offering home testing kits.
Earlier this week, surge testing began in the south London areas of Wandsworth and Lambeth.
The two boroughs are testing around 650,000 people after dozens of cases of the South African COVID variant were found there.
It is thought the first case was detected in a person who arrived in the UK from Africa in early March but the DHSC would only say that the first recorded incidence was "part of a household cluster".
That outbreak is believed to have then spread to a care home in Lambeth where 23 cases were reported.
It also spread to two primary schools in Wandsworth which have been offering extra surge testing.
A DHSC statement said: "Control measures were put in place within these settings as soon as COVID-19 cases were identified."
Huge queues formed on Wednesday at the testing sites in both boroughs.
According to government figures, there have been 533 genomically confirmed cases of the South African variant in the UK and another 11 probable cases.
Scientists have expressed some concern about the increase in cases coinciding with the easing of lockdown restrictions in England.
Professor Peter Openshaw, a member of the COVID-19 clinical information network, told BBC2’s Newsnight: "A lot of we scientists are very concerned about what’s happening at the moment.
"I think we’re all just hoping that the staged reduction in lockdown is going to be ok. It is being done reasonably cautiously but I think this is not good news.
"If we get rapid spread of the South African or other more resistant variants, it may well be that we are going to have to put the reductions of lockdown into reverse."