COVID-19 at lowest level since August – amid fears Indian variant could push infections back up

Coronavirus cases in England are at their lowest level since last August, a new study suggests – but it comes amid fears the rapid spread of the Indian variant could push infections up and impact the PM’s final step out of lockdown on 21 June.

The government’s Scientific Advisory Group for Emergencies (SAGE) is reportedly due to hold an emergency meeting today to discuss the Indian variant of concern and Boris Johnson’s roadmap out of lockdown.

The prime minister has said there is "increasing concern" in the UK about the variant first identified in India – and warned the emergence of further new variants "pose a potentially lethal danger".

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Asked about the Indian variant and whether it could delay the 21 June unlocking, Foreign Office minister James Cleverly told Sky News: "The scientists on SAGE will make their assessments, they will report back to government and we will make decisions based on the data and the evidence that they provide.

"The prime minister and the health secretary have always been clear that the easing of restrictions which will allow us to get back to normality will be done at a pace and in a way which is safe. We will always be driven by the data."

The European Medicines Agency said on Wednesday it was "pretty confident" that vaccines currently in use are effective against the Indian variant – a view echoed by some British scientists.

According to data from the latest round of the React-1 study, prevalence of COVID-19 infections dropped by 50% between March and early May – indicating the success of the vaccine rollout despite the relaxation of lockdown.

Between the last round which looked at data from March, and the current round which looked at data from April to the beginning of May, swab-positivity dropped by 50% in England from 0.20% to 0.10%. Experts estimate the corresponding R number to be 0.90.

The data includes 127,408 coronavirus swab tests carried out across England between 15 April and 3 May.

Researchers found there was a fall in all age groups except the 25 to 34-year-olds, with a "significant" fall in the 55 to 64-year-olds.

Professor Paul Elliott, director of the React programme, told a press briefing: "This coincides with the rollout of the vaccine programme to the younger part of that age group."

The data also suggests higher prevalence among the Asian community.

Researchers say the divergence between the pattern of infections and a pattern of hospital admissions and deaths suggests the rollout of mass vaccination is preventing severe outcomes.

Asked whether the data supported a move into the next stage of easing lockdown restrictions, Prof Elliott said: "It is a difficult question because we have low levels of prevalence in the community, and we’ve got low levels of disease in hospitals and deaths, so that’s good.

"But I think that the patterns in the Indian variant are cause for some concern."

He added that further studies are needed to really understand the characteristics and the spread of the Indian variant which appears to be at least as transmissible as the Kent variant.

Steven Riley, professor of infectious disease dynamics, Imperial College London, said: "What you can see in recent times – basically since the widespread rollout of the vaccine – and we showed this last time, that you see a decoupling of the relationship between the React infection and a lagged number of deaths.

"And this gap is showing how we can have more infections in the population with far fewer deaths.

"And we actually see that difference growing nicely now for hospitalisations as well, so for each infection in the community we are producing fewer hospitalisations and far fewer deaths."

Health Secretary Matt Hancock added: "Today’s findings demonstrate the impact our incredible vaccination rollout is having on COVID-19 infection rates across the country, with prevalence lowest amongst those more vulnerable people aged 65 and over."

Meanwhile, preliminary data in mixing vaccines has found an increased frequency of mild to moderate symptoms in those who received different jabs for the first and second dose.

The Com-Cov study was launched in February to investigate alternating doses of the Oxford/AstraZeneca and Pfizer Covid-19 jabs, with either being given as the first dose, and then the other as the second.

Reactions included symptoms like chills, fatigue, headaches and feeling feverish, and were short-lived, according to a peer-reviewed letter that has been printed in The Lancet.

There were no other safety concerns, researchers found.

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